Warren Rudman’s passion for public service was clear to anyone who met him. He was a tenacious prosecutor, a courageous combat infantry commander, and a devoted Senator. He knew as much about the federal budget as anyone who ever served in this town – and it was always a privilege to work with him, and learn from him. I was proud to call him a close personal friend and confidant. He never let politics stand in the way of doing what was right, and that’s why he had the absolute respect of Republicans and Democrats alike. Today, our thoughts and prayers are with all of Warren’s family and friends.
Wednesday, 21 November 2012
No hay más Led Zeppelin
By
<P>A pesar de lo dicho ayer, Peter Mensch, manager del guitarrista Jimmy Page, se retractó totalmente en eso que la banda buscaría un reemplazo al ultragenial Robert Plant para seguir rockeando y toureándola por el mundo tras su show de 2007 en el O2 Arena de Londres por el poder de la música más sexual de la historia. No habrá más Led Zeppelin, no hay planes de que lo haya.</P><P>Mensch comentó: "Led Zeppelin se acabó. Si no los vieron en el 2007, se los perdieron. Probaron reemplazantes a Robert Plant, pero nada funcionó. Se acabó. No hay planes para continuar. Francamente, ojalá todos dejaran de hablar al respecto."</P><P>Los fans no están nada contentos, especialmente los británicos, considerando los precios delirantes de las entradas del show reunión.</P><P>¿Y a ti? ¿Qué te parece todo esto?</P>
Related ArtistsSource:
http://www.mtv.com/news/articles/1602369/no-hay-mas-led-zeppelin.jhtml
Angelina Jolie Anna Faris Anna Friel Anna Kournikova Anna Paquin
Tuesday, 20 November 2012
Revised Article-Thrombocythemia and Thrombocytosis
Thrombocythemia and thrombocytosis are conditions in which your blood has a higher than normal number of platelets.
Source: http://www.nhlbi.nih.gov/health/health-topics/topics/thrm/
Diane Kruger Dido Diora Baird Dita Von Teese Dominique Swain
Delivery of Transthyretin (TTR) across the Blood Brain Barrier as a Treatment for Alzheimer's Disease
The invention describes products and methods of treating Alzheimer's disease. Alzheimer's disease is characterized by the formation of amyloid plaques and tangles in areas of the brain critical for learning and memory. The products are a transthyretin and other blood brain barrier impermeable proteins transformed into blood brain barrier permeable forms by the coupling of an Inter-Cellular Adhesion Molecule-1 (ICAM-1) targeting agent. Transthyretin binds to, and inhibits amyloid protein from forming plaque deposits. Deposition of amyloid is thought to underlie the disease pathology of Alzheimer's. Thus, this invention treats Alzheimer's by inhibiting the formation of amyloid plaques, which normally would result in amyloid plaque formation, inflammation, and neuronal cell death.
CRADA Opportunity: The NIH Chemical Genomics Center (NCGC) is open to collaborating in order to further develop this invention. Please contact Dr. Juan Marugan at maruganj@mail.nih.gov for more information about collaborative research opportunities.
CRADA Opportunity: The NIH Chemical Genomics Center (NCGC) is open to collaborating in order to further develop this invention. Please contact Dr. Juan Marugan at maruganj@mail.nih.gov for more information about collaborative research opportunities.
Source: http://www.ott.nih.gov/Technologies/abstractDetails.aspx?RefNo=2117
Emily Chew Joins ARVO Board of Trustees
Dr. Emily Chew was recently elected to the Association for Research in Vision and Ophthalmology (ARVO) Board of Trustees. She will serve as a Clinical/Epidemiologic Research Trustee. The board is comprised of elected members from ARVO's 13 scientific sections along with elected and trustee-appointed officers. It sets the strategic direction for ARVO and has the final responsibility and authority for all actions and policies that are recommended or adopted by standing and special committees, advisory councils and representatives to professional and governmental organizations, agents and employees.
Source: http://www.nei.nih.gov/news/briefs/chew_trustees.asp?nav=rss
Eliza Dushku Emilie de Ravin Emma Heming Emma Stone Emma Watson
Extended Comment Period on Proposed Adoption and Implementation of the Guide for the Care and Use of Laboratory Animals: Eighth Edition
NIH announces that the public comment period on the proposed adoption and implementation of the "Guide for the Care and Use of Laboratory Animals: Eighth Edition" has been extended until April 24, 2011. Comments may be submitted at http://grants.nih.gov/grants/olaw/2011guidecomments/add.htm.
Source: http://grants.nih.gov/grants/olaw/newsarchive_2011.htm#20110318
Ana Hickmann Ana Ivanovi Ana Paula Lemes Ananda Lewis Angela Marcello
Friedreich's Ataxia
Information on Freidreich's ataxia, compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: http://www.ninds.nih.gov/disorders/friedreichs_ataxia/friedreichs_ataxia.htm
New Report Highlights the Impact of the President’s Agenda on the Hispanic Community
Yesterday I had the pleasure of participating in a policy conversation held at the Center for American Progress on ensuring that the ladder of opportunity remains strong for the Latino community. In conjunction with that event we released a report, “An America Built to Last: President Obama’s Agenda and the Hispanic Community,” that takes a close look at the President’s agenda and how the Administration’s policies have made a difference for Hispanics and all Americans as we work to move our country forward out of the biggest economic crisis since the Great Depression.
The need for this report is simple. Latinos will account for 60 percent of the nation’s population growth in the coming decades, and in turn will be an increasingly larger share of our nation’s workforce. If our nation is going to be successful, we need a strong and well prepared workforce, so the success of our nation is tied directly to the success of the Hispanic community. That’s something President Obama understands, and why he has made it a priority that his Administration is not only reflective of America’s great diversity, but that we’re being open and responsive to the needs of all Americans.
So this report looks at what the policies and programs of this Administration have meant for Hispanic Americans throughout the last three and a half years. The report highlights:
- How policies in the Recovery Act, including tax cuts for working families and improvements in unemployment insurance, combined to keep over 2 million Hispanics out of poverty in 2010.
- How the tax agreement the President fought for extended key provisions including the Earned Income Tax Credit (EITC) and the Child Tax Credit (CTC) that directly benefit an estimated 3.7 million Hispanic families, including 8 million Hispanic children.
- How the payroll tax cut the President fought for ensures that taxes do not go up on nearly 25 million Hispanic workers.
- How since the start of the Administration through March 31, 2012, more than $3.8 billion in over 10,800 Small Business Administration loans went to Hispanic-owned small businesses including more than $128 million through nearly 300 international trade loans.
- The report also highlights how the Consumer Financial Protection Bureau is working on behalf of Hispanic consumers, including taking on deceptive credit card practices, and providing protections for those who use remittance service providers and payday lenders.
- Because education is such an important issue for this community, the report also has an extensive section on what’s being done to improve education from cradle to career and how these reforms affect a community in which only 56 percent of Latino students graduate on time from high school.
- Along those lines, the report highlights how more than 150,000 Hispanic students stand to benefit from the increases in Pell Grants. The Obama Administration has raised the maximum Pell Grant award and has provided resources to support an additional three million Pell Grant recipients, a 50 percent increase in students served since 2008.
- The report also details the Administration’s work toward immigration reform, and improvements that have been made in both border security and immigration enforcement, as well as in streamlining and improving the legal immigration process.
- Civil rights have also been at the forefront of the efforts of this Administration. So this report looks at how the Department of Justice and Civil Rights divisions throughout the government are enforcing our nation’s civil rights laws, and what that means for the Hispanic community. Everything from proteting victims of crimes and abuse, to protections for farm workers, to enforcing hate crime laws and protecting migrants and guest workers against human trafficking.
- And since more than 210,000 Hispanic soldiers are currently serving in the U.S. Armed Forces and we have over 1.1 million Hispanic veterans, the report looks at what our Administration is doing to make college more accessible for veterans, to make tax credits available for them, to help more veterans start businesses, and to increase access to intensive reemployment services.
The report is now available at www.whitehouse.gov/hispanic, and www.whitehouse.gov/espanol in Spanish. Take a look, let us know what you think.
Christina Ricci Chyler Leigh Ciara Cindy Crawford Cindy Taylor
Revised Spanish Article-Hemophilia
Hemophilia (heem-o-FILL-ee-ah) is a rare bleeding disorder in which the blood doesn't clot normally.
Source: http://www.nhlbi.nih.gov/health-spanish/health-topics/temas/hemofilia/
Beyonc? Bianca Kajlich Bijou Phillips Blake Lively Blu Cantrell
NIH researchers implicate unique cell type in multiple sclerosis
Researchers at the National Institutes of Health have found evidence that a unique type of immune cell contributes to multiple sclerosis (MS). Their discovery helps define the effects of one of the newest drugs under investigation for treating MS – daclizumab – and could lead to a new class of drugs for treating MS and other autoimmune disorders.
Source: http://www.ninds.nih.gov/news_and_events/news_articles/MS_drug.htm
Gretha Cavazzoni Gwen Stefani Halle Berry Hayden Panettiere Haylie Duff
IACUC Administrator’s Best Practices Meeting: November 2010, State College, PA
The Pennsylvania State University is presenting the "5th Annual IACUC Administrator's Best Practices Meeting." Two sessions will be held on November 9-10 and 11-12, 2010 in State College, Pennsylvania. Program information can be found on the OLAW website in the Education Section under Workshops and Conferences at http://grants.nih.gov/grants/olaw/workshop.htm.
Source: http://grants.nih.gov/grants/olaw/newsarchive_2010.htm#20101021
Donna Feldman Drea de Matteo Drew Barrymore Ehrinn Cummings Elena Lyons
New Forum for Submitting Comments on the OLAW Online Seminars
OLAW has developed an online forum for participants and viewers of the OLAW Online Seminars. If you have participated in the Online Seminar, "What Every IACUC Should Know About AAALAC International", or watched the recording, you may now submit comments and questions online. OLAW will compile comments, answer questions and post relevant material on the OLAW website. The comment period for this seminar is open until August 15, 2009. The link to the forum can be found on the Education Resources page by clicking on the seminar title.
Source: http://grants.nih.gov/grants/olaw/newsarchive_2009.htm#20090707
Jennifer Love Hewitt Jennifer Morrison Jennifer ODell Jennifer Scholle Jennifer Sky
Monday, 19 November 2012
“IACUC Responsibilities Beyond Protocol Review and Facilities Inspection” Seminar Available for Viewing
A recording of the OLAW IACUC Staff Online Seminar, "IACUC Responsibilities Beyond Protocol Review and Facilities Inspection", held March 10, 2011 has been posted on the OLAW website. The seminar recording and supporting materials can be found at http://grants.nih.gov/grants/olaw/educational_resources.htm.
Source: http://grants.nih.gov/grants/olaw/newsarchive_2011.htm#20110317
Ana Paula Lemes Ananda Lewis Angela Marcello Angelina Jolie Anna Faris
Revised Article-Pleurisy and Pleural Disorders
Read this article to learn about pleurisy and other pleural disorders.
Source: http://www.nhlbi.nih.gov/health/dci/Diseases/pleurisy/pleurisy_whatare.html
Deanna Russo Denise Richards Desiree Dymond Diane Kruger Dido
November Partner Spotlight
Check out the NDEP's partner in the November spotlight.
Source: http://ndep.nih.gov/whats-new/posting.aspx?id=92
Izabella Miko Izabella Scorupco Jaime King Jaime Pressly Jamie Chung
New Article-Respiratory Failure
Respiratory failure is a condition in which not enough oxygen passes from your lungs into your blood.
Source: http://www.nhlbi.nih.gov/health/dci/Diseases/rf/rf_whatis.html
Alessandra Ambrosio Alexis Bledel Ali Campoverdi Ali Larter Alice Dodd
Update of the Guide for the Care and Use of Laboratory Animals
The Institute for Laboratory Animal Research of the National Academy of Sciences has released a prepublication copy of the 8th Edition of the "Guide for the Care and Use of Laboratory Animals."
Source: http://grants.nih.gov/grants/olaw/newsarchive_2010.htm#20100602
Emilie de Ravin Emma Heming Emma Stone Emma Watson Emmanuelle Chriqui
ILAR Journal Volume 50(2): Gene Therapy in Large Animal Models of Human Genetic Diseases
Gene Therapy in Large Animal Models of Human Genetic Diseases. "The structure and function of most genes in animals are homologous to those in humans, thus many genetic diseases that occur in humans also occur in animals. Gene mutations usually cause similar biochemical dysfunctions, resulting in pathologic changes at the molecular, cellular, organ, and organism levels. For these reasons, the knowledge gained through research in animals can be of direct benefit to human as well as animal health." Issue editor: John H. Wolfe
Source: http://grants.nih.gov/grants/olaw/newsarchive_2009.htm#20090401
Arielle Kebbel Ashanti Ashlee Simpson Ashley Greene Ashley Olsen
Revised Article-Heart Murmur
A heart murmur is an extra or unusual sound heard during a heartbeat.
Source: http://www.nhlbi.nih.gov/health/dci/Diseases/heartmurmur/hmurmur_what.html
Jessica Alba Jessica Biel Jessica Cauffiel Jessica Par? Jessica Simpson
Patient-derived stem cells could improve drug research for Parkinson's
Researchers have taken a step toward better drug therapies for Parkinson's disease and Huntington's disease by investigating signs of distress and vulnerability in patient-derived cells. Cells derived from patients with Parkinson's had different responses to drug treatments depending on the type of Parkinson's each patient had. These are the latest advances from the NINDS iPS cell consortia.
Source: http://www.ninds.nih.gov/news_and_events/news_articles/pressrelease_nih_stem_cells.htm
Amanda Righetti Amanda Swisten Amber Arbucci Amber Brkich Amber Heard
Multiple Sclerosis
Multiple Sclerosis (MS) information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: http://www.ninds.nih.gov/disorders/multiple_sclerosis/multiple_sclerosis.htm
Izabella Scorupco Jaime King Jaime Pressly Jamie Chung Jamie Gunns
Carpal Tunnel Syndrome
Carpal tunnel syndrome information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: http://www.ninds.nih.gov/disorders/carpal_tunnel/carpal_tunnel.htm
Gabrielle Union Garcelle Beauvais Genelle Frenoy Georgianna Robertson Georgina Grenville
Sunday, 18 November 2012
Fenoterol and Fenoterol Analogues for Treatment of Glioma, Glioblastoma, and Astrocytoma
To date there is no effective treatment for the brain tumors or brain cancers indentified as gliomas, glioblastomas, or astrocytomas.
This technology relates to the discovery that fenoterol and related analogues block astrocytoma and glioblastoma cell division at low doses. In a xenograft model utilizing the 1321N1 astrocytoma tumor implanted in the flank of SKID mice, the (R,R)-4-methoxyfenoterol analogue significantly decreased tumor growth relative to a control group receiving vehicle and studies utilizing [3H]-(R,R)-4-methoxyfenoterol have shown that the compound readily passes the blood-brain barrier. The anti-tumor effect is associated with the ability of fenoterol and related analogues to induce production of cyclic adenosine monophosphate (cAMP), which is normally decreased in glioblastomas and astrocytomas. Induced cAMP production inhibits brain tumor growth in vivo. Fenoterol and related analogues are beta-2 adrenergic receptor (beta2 AR) agonists and the anti-tumor effect is associated with the expression of this receptor. Since there is a heterogeneous expression of beta2 AR in human brain tumors, patients who will respond to fenoterol therapy can be predetermined leading to individualized treatment. In addition to use in the initial treatment of brain tumors, the systemic and CNS bioavailability of the drug after oral administration and the minimal systemic toxicity suggest that fenoterol and it analogs can be used in the adjuvant treatment of patients with beta2 AR-positive gliomas, glioblastomas or astrocytomas. Studies with a number of fenoterol analogs and CNS-implanted tumors are in progress.
The fenoterol analogues discussed in this technology are subject to HHS Ref. No. E-205-2006/3 (U.S. Patent Application No. 12/376,945 and PCT Publication No. WO/2008/022038). CRADA Opportunity: The National Institute on Aging, Laboratory of Clinical Investigation, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the use of fenoterol and fenoterol analogs in the front line and adjuvant treatment of CNS tumors and other beta2 AR expressing tumors. Please contact Nicole Guyton, Ph.D. at 301-435-3101 or darackn@mail.nih.gov for more information. Click here to view the NIA collaborative opportunity announcement.
This technology relates to the discovery that fenoterol and related analogues block astrocytoma and glioblastoma cell division at low doses. In a xenograft model utilizing the 1321N1 astrocytoma tumor implanted in the flank of SKID mice, the (R,R)-4-methoxyfenoterol analogue significantly decreased tumor growth relative to a control group receiving vehicle and studies utilizing [3H]-(R,R)-4-methoxyfenoterol have shown that the compound readily passes the blood-brain barrier. The anti-tumor effect is associated with the ability of fenoterol and related analogues to induce production of cyclic adenosine monophosphate (cAMP), which is normally decreased in glioblastomas and astrocytomas. Induced cAMP production inhibits brain tumor growth in vivo. Fenoterol and related analogues are beta-2 adrenergic receptor (beta2 AR) agonists and the anti-tumor effect is associated with the expression of this receptor. Since there is a heterogeneous expression of beta2 AR in human brain tumors, patients who will respond to fenoterol therapy can be predetermined leading to individualized treatment. In addition to use in the initial treatment of brain tumors, the systemic and CNS bioavailability of the drug after oral administration and the minimal systemic toxicity suggest that fenoterol and it analogs can be used in the adjuvant treatment of patients with beta2 AR-positive gliomas, glioblastomas or astrocytomas. Studies with a number of fenoterol analogs and CNS-implanted tumors are in progress.
The fenoterol analogues discussed in this technology are subject to HHS Ref. No. E-205-2006/3 (U.S. Patent Application No. 12/376,945 and PCT Publication No. WO/2008/022038). CRADA Opportunity: The National Institute on Aging, Laboratory of Clinical Investigation, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the use of fenoterol and fenoterol analogs in the front line and adjuvant treatment of CNS tumors and other beta2 AR expressing tumors. Please contact Nicole Guyton, Ph.D. at 301-435-3101 or darackn@mail.nih.gov for more information. Click here to view the NIA collaborative opportunity announcement.
Source: http://www.ott.nih.gov/Technologies/abstractDetails.aspx?RefNo=2160
Jamie Gunns Jamie Lynn Sigler Janet Jackson January Jones Jennie Finch
Spasticity
Spasticity information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke.
Source: http://www.ninds.nih.gov/disorders/spasticity/spasticity.htm
Amanda Swisten Amber Arbucci Amber Brkich Amber Heard Amber Valletta
iPhoto '09 & iPhoto '11: Editing photos in iPhoto will not refresh image in Flickr gallery
If you have published images to your Flickr account from iPhoto '09 or iPhoto '11, attempting to edit these images from your iPhoto application and then republishing to your Flickr account will not replace your published photo with your new image.
Source: http://support.apple.com/kb/TS2549
Busy Philipps Cameron Diaz Cameron Richardson Camilla Belle Carla Campbell
Britney Spears - Till the World Ends
- Artist: Britney Spears
- Label: Jive
- Director: Ray Kay
- Album: Metamora
Source:
http://www.mtv.com/overdrive/?artist=501686&vid=639722
Brooke Burns Busy Philipps Cameron Diaz Cameron Richardson Camilla Belle
Batten Disease
Batten Disease information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke.
Source: http://www.ninds.nih.gov/disorders/batten/batten.htm
Anne Marie Kortright April Scott Arielle Kebbel Ashanti Ashlee Simpson
Arachnoiditis
Arachnoiditis information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: http://www.ninds.nih.gov/disorders/arachnoiditis/arachnoiditis.htm
Gina Gershon Gina Philips Giuliana DePandi Giulianna Ramirez Grace Park
Mucopolysaccharidoses
Mucopolysaccharidoses (MPS) fact sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: http://www.ninds.nih.gov/disorders/mucopolysaccharidoses/mucopolysaccharidoses.htm
Jamie Chung Jamie Gunns Jamie Lynn Sigler Janet Jackson January Jones
FY 12 Third Quarter Results Conference Call
WHAT: Apple® FY 12 Third Quarter Results Conference Call
WHERE: Via conference call. The dial-in number for press is (877) 616-0062 (toll-free) or (719) 219-0039. Please enter confirmation code 691025.
WHEN: Tuesday, July 24, 2012, 2:00 p.m. PDT/5:00 p.m. EDT
REBROADCAST: The conference call will be available as a continuous rebroadcast beginning Tuesday, July 24 at 5:30 p.m. PDT/8:30 p.m. EDT through Tuesday, August 7 at 5:30 p.m. PDT/8:30 p.m. EDT. The dial-in number for the rebroadcast is (888) 203-1112 (toll-free) or (719) 457-0820. Please enter confirmation code 1260435.
WEBCAST: Apple will provide live audio streaming of its FY 12 Third Quarter Results Conference Call using Apple’s industry-leading QuickTime® multimedia software. The live webcast will begin at 2:00 p.m. PDT on July 24, 2012 at www.apple.com/quicktime/qtv/earningsq312 and will also be available for replay for approximately two weeks thereafter. The webcast is available on any iPhone®, iPad® or iPod touch® running iOS 4.2 or above, any Mac® running OS X 10.5 or above or any PC running QuickTime 7 or later. If you do not have QuickTime installed on your Windows PC, it is available at www.apple.com/quicktime.
This recording is the property of Apple and protected by US copyright law and international treaties. Any reproduction or distribution is strictly prohibited without prior written approval from Apple. Please contact Apple Public Relations or Investor Relations with any questions.
Apple designs Macs, the best personal computers in the world, along with OS X, iLife, iWork and professional software. Apple leads the digital music revolution with its iPods and iTunes online store. Apple has reinvented the mobile phone with its revolutionary iPhone and App Store, and is defining the future of mobile media and computing devices with iPad.
Press Contacts:
Steve Dowling
Apple
dowling@apple.com
974-1896
Kristin Huguet
Apple
khuguet@apple.com
(408) 974-2414
WHERE: Via conference call. The dial-in number for press is (877) 616-0062 (toll-free) or (719) 219-0039. Please enter confirmation code 691025.
WHEN: Tuesday, July 24, 2012, 2:00 p.m. PDT/5:00 p.m. EDT
REBROADCAST: The conference call will be available as a continuous rebroadcast beginning Tuesday, July 24 at 5:30 p.m. PDT/8:30 p.m. EDT through Tuesday, August 7 at 5:30 p.m. PDT/8:30 p.m. EDT. The dial-in number for the rebroadcast is (888) 203-1112 (toll-free) or (719) 457-0820. Please enter confirmation code 1260435.
WEBCAST: Apple will provide live audio streaming of its FY 12 Third Quarter Results Conference Call using Apple’s industry-leading QuickTime® multimedia software. The live webcast will begin at 2:00 p.m. PDT on July 24, 2012 at www.apple.com/quicktime/qtv/earningsq312 and will also be available for replay for approximately two weeks thereafter. The webcast is available on any iPhone®, iPad® or iPod touch® running iOS 4.2 or above, any Mac® running OS X 10.5 or above or any PC running QuickTime 7 or later. If you do not have QuickTime installed on your Windows PC, it is available at www.apple.com/quicktime.
This recording is the property of Apple and protected by US copyright law and international treaties. Any reproduction or distribution is strictly prohibited without prior written approval from Apple. Please contact Apple Public Relations or Investor Relations with any questions.
Apple designs Macs, the best personal computers in the world, along with OS X, iLife, iWork and professional software. Apple leads the digital music revolution with its iPods and iTunes online store. Apple has reinvented the mobile phone with its revolutionary iPhone and App Store, and is defining the future of mobile media and computing devices with iPad.
Press Contacts:
Steve Dowling
Apple
dowling@apple.com
974-1896
Kristin Huguet
Apple
khuguet@apple.com
(408) 974-2414
Source: http://www.apple.com/pr/library/2012/07/20FY-12-Third-Quarter-Results-Conference-Call.html
Ashley Tappin Ashley Tisdale Asia Argento Aubrey ODay Audrina Patridge
Aspirin-clopidogrel no better than aspirin alone for patients with lacunar stroke
An NIH-funded trial has found that aspirin combined with the antiplatelet drug clopidogrel is no better than aspirin alone for stroke prevention in people with a history of lacunar strokes, which are typically small strokes that occur deep within the brain. The trial also found that whether patients received aspirin or the dual therapy, their stroke risk was reduced more than three-fold from what it was 10 years ago.
Source: http://www.ninds.nih.gov/news_and_events/news_articles/SPS3_antiplatelet_results.htm
FSU Cowgirls Gabrielle Union Garcelle Beauvais Genelle Frenoy Georgianna Robertson
Intestinal Mending Depends on Key Protein
Source: http://www.nih.gov/researchmatters/october2012/10152012intestinal.htm
Jennifer Gareis Jennifer Garner Jennifer Gimenez Jennifer Love Hewitt Jennifer Morrison
An Antibody Specific for the Ubl4A Protein
The antibody developed against the Ubl4A protein is available for licensing. Ubl4A is involved in the proper targeting of tail-anchored proteins to membranes by acting as a chaperone to prevent inappropriate interactions or aggregation. Alterations in membrane insertion or protein degradation may be related to Ubl4a in certain disease states making Ubl4a an attractive biomarker for the study of disease development or as a tool for the development of assays for disease detection.
CRADA Opportunity: The NICHD is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Ubl4A assay detection for disease diagnostics. Please contact Charlotte McGuinness at 301-435-3130 or mcguinnc@mail.nih.gov for more information.
CRADA Opportunity: The NICHD is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Ubl4A assay detection for disease diagnostics. Please contact Charlotte McGuinness at 301-435-3130 or mcguinnc@mail.nih.gov for more information.
Source: http://www.ott.nih.gov/Technologies/abstractDetails.aspx?RefNo=2282
Elisha Cuthbert Eliza Dushku Emilie de Ravin Emma Heming Emma Stone
New FAQ on Protocol Review Posted
A new Frequently Asked Question (FAQ) has been posted on the OLAW website. This FAQ provides guidance on the topic "Does the IACUC have to review proposed animal research activities at the time of grant award if the animal research activities will not be conducted until year 4 or 5 of a grant?"
Source: http://grants.nih.gov/grants/olaw/newsarchive_2009.htm#20090116
Emma Heming Emma Stone Emma Watson Emmanuelle Chriqui Emmanuelle Vaugier
Saturday, 17 November 2012
Updated Guidance in Lab Animal Protocol Review Column: November Issue
Visit the Guidance section on the OLAW website for updated Commentary on Lab Animal Protocol Review columns. "A word from OLAW and USDA" responds to the topic "Amendment submitted; protocol reviewed?" in the November 2012 issue. See http://go.usa.gov/7br.
Source: http://grants.nih.gov/grants/olaw/news.htm#20121107
Jennifer Love Hewitt Jennifer Morrison Jennifer ODell Jennifer Scholle Jennifer Sky
Metachromatic Leukodystrophy
Metachromatic Leukodystrophy information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: http://www.ninds.nih.gov/disorders/metachromatic_leukodystrophy/metachromatic_leukodystrophy.htm
Ehrinn Cummings Elena Lyons Elisha Cuthbert Eliza Dushku Emilie de Ravin
Estimate Your Social Security Benefit!
You can get an instant, personalized estimate of your Social Security retirement benefits by using the Retirement Estimator on the Social Security Administration (SSA) website. If you have questions, please contact an SSA representative at 1-800-772-1213, TTY: 1-800-325-0778, between 7:00 a.m. and 7:00 p.m., Monday through Friday.
Source: http://hr.od.nih.gov/benefits/news/default.htm#SS
Dido Diora Baird Dita Von Teese Dominique Swain Donna Feldman
Revised Article-Antiphospholipid Antibody Syndrome
Antiphospholipid antibody syndrome is an autoimmune disorder.
Source: http://www.nhlbi.nih.gov/health/health-topics/topics/aps/
Erika Christensen Estella Warren Eva Green Eva Longoria Eva Mendes
'Breaking Dawn' Shooting Plot Shut Down In Missouri
Blaec Lammer was arrested after admitting he planned to shoot up a local movie theater.
By Kara Warner
Blaec James Lammers
Photo: Polk County Sheriff's Dept.
Gina Carano Gina Gershon Gina Philips Giuliana DePandi Giulianna Ramirez
The Employee Benefits Information System (EBIS) has now launched.
NIH has launched a new system called Employee Benefits Information System (EBIS). The Employee Benefits Information System provides employees with 24-hour online access to personal and general information about retirement and benefits. To find out more about EBIS please visit the HR Systems webpage.
Source: http://hr.od.nih.gov/hrsystems/benefits/ebis/default.htm
Britney Spears Brittany Daniel Brittany Lee Brittany Murphy Brittany Snow
Deferred Action for Childhood Arrivals: Who Can Be Considered?
Ed. note: This post was originally published on dhs.gov.
Today, the U.S. Citizenship and Immigration Services will begin accepting requests for consideration of deferred action for childhood arrivals. Deferred action is a discretionary determination to defer removal action of an individual as an act of prosecutorial discretion. Under this process, USCIS will consider requests on a case-by-case basis. While this process does not provide lawful status or a pathway to permanent residence or citizenship, individuals whose cases are deferred will not be removed from the United States for a two year period, subject to renewal, and may also receive employment authorization. To be considered for this process, you must show that:
- You came to the United States before reaching your 16th birthday
- You have continuously resided in the United States since June 15, 2007, up to the present time
- You were under the age of 31 as of June 15, 2012
- You entered without inspection before June 15, 2012, or your lawful immigration status expired as of June 15, 2012
- You are currently in school, have graduated or obtained your certificate of completion from high school, have obtained your general educational development certification, or you are an honorably discharged veteran of the Coast Guard or Armed Forces of the United States
- You have not been convicted of a felony, significant misdemeanor, or three or more misdemeanors, and do not otherwise pose a threat
- You were present in the United States on June 15, 2012, and at the time of making your request for consideration of deferred action with USCIS
If you meet the above guidelines, and want to submit your deferred action for childhood arrivals request with USCIS, you will need to:
- Collect documents as evidence you meet the guidelines
- Complete USCIS Forms I-821D, I-765 and I-765 Worksheet
- Mail USCIS the forms and fees (total $465, accompanying Form I-765)
- Visit your local USCIS Application Support Center for a scheduled biometrics services appointment
After you file, you will be able to check the status of your request online. For more information, visit our website for the latest news and updates on this process at www.uscis.gov/childhoodarrivals.
Watch the Deferred Action for Childhood Arrivals process here.
Source: http://www.whitehouse.gov/blog/2012/08/15/deferred-action-childhood-arrivals-who-can-be-considered
Carla Campbell Carla Gugino Carmen Electra Carol Grow Carrie Underwood
Readout of the President’s Phone Calls with Israeli Prime Minister Netanyahu and Egyptian President Morsi
Today, the President spoke with Prime Minister Netanyahu and President Morsi about the rocket attacks being launched from Gaza into Israel, and the escalating violence in Gaza.
The President reiterated to Prime Minister Netanyahu the United States’ support for Israel’s right to self-defense in light of the barrage of rocket attacks being launched from Gaza against Israeli civilians. The President urged Prime Minister Netanyahu to make every effort to avoid civilian casualties. The two agreed that Hamas needs to stop its attacks on Israel to allow the situation to de-escalate. The two leaders agreed to stay in close touch in the coming days. Earlier today, Vice President Biden received a briefing from Prime Minister Netanyahu on the events in Gaza.
The President also spoke with President Morsi given Egypt’s central role in preserving regional security. In their conversation, President Obama condemned the rocket fire from Gaza into Israel and reiterated Israel’s right to self-defense. The two leaders agreed on the importance of working to de-escalate the situation as quickly as possible and agreed to stay in close touch in the days ahead.
Bijou Phillips Blake Lively Blu Cantrell Bonnie Jill Laflin Bridget Moynahan
Revised Article-Atherosclerosis
Atherosclerosis is a disease in which plaque (plak) builds up inside your arteries.
Source: http://www.nhlbi.nih.gov/health/dci/Diseases/Atherosclerosis/Atherosclerosis_WhatIs.html
Anna Kournikova Anna Paquin AnnaLynne McCord Anne Marie Kortright April Scott
Readout of the President’s Phone Call with Turkish Prime Minister Erdogan
Today, the President called Prime Minister Erdogan to discuss the escalating violence in Israel and the Gaza Strip. The two leaders shared their concerns about the dangers to civilian populations on both sides and expressed their common desire to see an end to the violence. The President and Prime Minister agreed that the continued spiral of violence jeopardizes prospects for a durable, lasting peace in the region. The President underscored his commitment to advancing the goal of Middle East peace. The President’s call to Prime Minister Erdogan follows his outreach to counterparts in Israel and Egypt on November 14.
Donna Feldman Drea de Matteo Drew Barrymore Ehrinn Cummings Elena Lyons
Thyrotoxic Myopathy
Thyrotoxic Myopathy information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: http://www.ninds.nih.gov/disorders/thyrotoxic_myopathy/thyrotoxic_myopathy.htm
Brody Dalle Brooke Burke Brooke Burns Busy Philipps Cameron Diaz
Post-Polio Syndrome
Post-Polio syndrome information compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: http://www.ninds.nih.gov/disorders/post_polio/post_polio.htm
Anna Paquin AnnaLynne McCord Anne Marie Kortright April Scott Arielle Kebbel
Friday, 16 November 2012
Inverse Agonists of the TSH Receptor for the Treatment of Thyroid Cancer and Hyperthyroidism
This technology features small molecule inverse agonists of the thyroid-stimulating hormone (TSH) receptor that may be readily synthesized, and are likely to prove effective for oral administration. These compounds may potentially be used to treat recurrent thyroid cancer and some cases of hyperthyroidism, and also represent unique tools for investigating the role of TSH receptor signaling in these diseases.
According to the National Cancer Institute, over 37,000 new cases of thyroid cancer were diagnosed in the United States in 2008. Approximately 10% to 30% of patients thought to be disease-free after initial treatment will develop recurrent cancer or metastases, and unless the recurrence is detected early, the prognosis is generally poor.
As the TSH receptor is known to stimulate proliferation of thyroid cancer cells, it has been suggested that suppression of basal TSH receptor signaling may improve outcomes in the treatment of recurrent thyroid cancer. The compounds disclosed in this technology suppress basal signaling by the TSH receptor, and are thus excellent candidates for a suppression-based treatment approach. CRADA Opportunity: The NIDDK Office of Technology Transfer and Development is seeking statements of capability or interest from parties interested in collaborative research to further develop inverse agonists of the TAS receptor. Please contact Marguerite J. Miller at 301-496-9003 or millermarg@mail.nih.gov for more information.
According to the National Cancer Institute, over 37,000 new cases of thyroid cancer were diagnosed in the United States in 2008. Approximately 10% to 30% of patients thought to be disease-free after initial treatment will develop recurrent cancer or metastases, and unless the recurrence is detected early, the prognosis is generally poor.
As the TSH receptor is known to stimulate proliferation of thyroid cancer cells, it has been suggested that suppression of basal TSH receptor signaling may improve outcomes in the treatment of recurrent thyroid cancer. The compounds disclosed in this technology suppress basal signaling by the TSH receptor, and are thus excellent candidates for a suppression-based treatment approach. CRADA Opportunity: The NIDDK Office of Technology Transfer and Development is seeking statements of capability or interest from parties interested in collaborative research to further develop inverse agonists of the TAS receptor. Please contact Marguerite J. Miller at 301-496-9003 or millermarg@mail.nih.gov for more information.
Source: http://www.ott.nih.gov/Technologies/abstractDetails.aspx?RefNo=2172
Audrina Patridge Autumn Reeser Avril Lavigne Bali Rodriguez Bar Refaeli
Training in Basic Biomethodology for Laboratory Rats
The National Human Genome Research Institute Office of Laboratory Animal Medicine, with support from the NIH Office of Animal Care and Use and the AALAS Foundation, has developed a training CD in "Basic Biomethodology for Laboratory Rats". To obtain a copy of the CD send your name, research institution affiliation, full mailing address and email address to rats_cd@mail.nih.gov. One CD per request please.
Source: http://grants.nih.gov/grants/olaw/newsarchive_2009.htm#20091204
Emmy Rossum Erica Leerhsen Erika Christensen Estella Warren Eva Green
Final Cut Pro X, Motion 5, Compressor 4: Issue when sharing a project to Vimeo with an ampersand (&) in the title
If you share a Project to Vimeo that has an ampersand (&) in the name of the project, the title may be shortened. The title of the video on Vimeo will only include the part of the project title before the ampersand.
Source: http://support.apple.com/kb/TS4454
Jennifer Gimenez Jennifer Love Hewitt Jennifer Morrison Jennifer ODell Jennifer Scholle
New Cholera Vaccine and Method for Conjugating Bacterial Polysaccharides to Proteins
A new conjugate vaccine for cholera has been developed. The invention includes a new method to conjugate the O-specific polysaccharide-core part of the bacterial lipopolysaccharide and protein subcomponents. Conventional technology has entailed chemical treatment of both components to introduce linkers, which made them amenable for covalent linking. The new method simplifies production by utilizing squaric acid chemistry for conjugating the free amine-containing species (e.g. polysaccharides) directly to amine-containing species (e.g. proteins) without prior modification of either component. While demonstrated in this new cholera prototype vaccine, the technology is envisioned as generally applicable, thereby streamlining a complex production process.
CRADA Opportunity: The National Institute of Diabetes and Digestive and Kidney Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize conjugate vaccines. For collaboration opportunities, please contact Marguerite J. Miller, M.B.A. at 301-496-9003 or millermarg@niddk.nih.gov.
CRADA Opportunity: The National Institute of Diabetes and Digestive and Kidney Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize conjugate vaccines. For collaboration opportunities, please contact Marguerite J. Miller, M.B.A. at 301-496-9003 or millermarg@niddk.nih.gov.
Source: http://www.ott.nih.gov/Technologies/abstractDetails.aspx?RefNo=2349
Jennifer Morrison Jennifer ODell Jennifer Scholle Jennifer Sky Jenny McCarthy
Readout of the Vice President's Call with Ukrainian President Viktor Yanukovych
Vice President Biden spoke to the President of Ukraine, Viktor Yanukovych, today to thank him for his congratulatory message following last week’s U.S. election. Noting the strong interest of the United States in enhancing its relationship with Ukraine, the Vice President voiced concerns over Ukraine’s recent parliamentary elections and asked President Yanukovych to ensure the process is completed in a fair and transparent manner. He also urged Ukraine to live up to its democratic commitments and end selective prosecutions.
Anna Faris Anna Friel Anna Kournikova Anna Paquin AnnaLynne McCord
Funded by National Eye Institute, Makers of Bionic Eye Receive Eight Millionth Patent
The Argus II retinal prosthesis, developed by Second Sight, Inc., with funding from the National Eye Institute (NEI), was recognized September 8, 2011, in honor of being the 8 millionth patent issued by the United States Patent and Trademark Office (USPTO). The Argus II is a device that restores limited sight to the blind.
Source: http://www.nei.nih.gov/news/briefs/bionic_eye.asp?nav=rss
Foxy Brown Freida Pinto FSU Cowgirls Gabrielle Union Garcelle Beauvais
Updated OHR Retirement Information
Check out our new, updated OHR retirement web page! If you visit us at http://www.hr.od.nih.gov/benefits/retirement you will see that we have made some changes. The first link still provides NIH employees the ability to quickly and easily request a retirement estimate – a tool powered by WiTS. The second link now has available all of the retirement forms and information that an employee needs to retire – available in pdf format for easy completion. Simply click on the appropriate retirement system (CSRS or FERS) – it's all there. In addition, you will find links to lots of information such as your Federal health plan and Medicare, Thinking About Retirement – things to consider, and New Retiree FAQs. And the on-line tools will assist you in planning for retirement. Tools include a calculators for retirement estimates, Federal and state tax, TSP annuities, and life insurance.
Source: http://hr.od.nih.gov/benefits/retirement
Brody Dalle Brooke Burke Brooke Burns Busy Philipps Cameron Diaz
Multiple System Atrophy
Information sheet on Multiple System Atrophy compiled by NINDS.
Source: http://www.ninds.nih.gov/disorders/msa/msa.htm
Giuliana DePandi Giulianna Ramirez Grace Park Gretha Cavazzoni Gwen Stefani
Revised Article-Heart Block
Heart block is a problem that occurs with the hearts electrical system.
Source: http://www.nhlbi.nih.gov/health/dci/Diseases/hb/hb_whatis.html
Danneel Harris Deanna Russo Denise Richards Desiree Dymond Diane Kruger
Student's Lab Experience at NEI
The crowded Metro train screeched to a stop. Medical Center, red line to Shady Grove, the driver announced over the loudspeaker. I threw my backpack over my shoulder, climbed the monstrous escalator, and walked out into the almost unbearbable summer heat toward the entrance to the National Institutes of Health in Bethesda, Md. After having my badge scanned at the front gate, I made my way to the National Eye Institute in Building 10, NIHs Clinical Center. I boarded a packed elevator, rode up to the tenth floor, and headed down the long hallway to my laboratory, the doors of which were decorated with postcards from all over the world and Biosafety Level 2 signs.
Source: http://www.nei.nih.gov/news/briefs/studentslabexperience.asp?nav=rss
Zooey Deschanel Aaliyah Abbie Cornish Adriana Lima Adrianne Curry
Thursday, 15 November 2012
Revised Article-High Blood Pressure
High blood pressure is a serious condition that can lead to coronary heart disease (also called coronary artery disease), heart failure, stroke, kidney failure, and other health problems.
Source: http://www.nhlbi.nih.gov/health/dci/Diseases/Hbp/HBP_WhatIs.html
Angelina Jolie Anna Faris Anna Friel Anna Kournikova Anna Paquin
Mountain Lion: About Power Nap
Learn about Power Nap.
Source: http://support.apple.com/kb/HT5394
Avril Lavigne Bali Rodriguez Bar Refaeli Beyonc? Bianca Kajlich
USDA AWIC Workshop: October 3-4, Beltsville, MD
The USDA Animal Welfare Information Center teaches a workshop at the National Agricultural Library in Beltsville, MD for individuals who are responsible for providing information to meet the requirements of the Animal Welfare Act. The next workshop is October 3-4, 2012. For more information, go to http://go.usa.gov/rMzW.
Source: http://grants.nih.gov/grants/olaw/news.htm#20120920
Giuliana DePandi Giulianna Ramirez Grace Park Gretha Cavazzoni Gwen Stefani
Upcoming Benefits Events
Upcoming NIH Benefits events ranging from Retirement Seminar, Retirement Readiness – More Than Just A Paycheck, Blue Cross/Blue Shield (BCBS) Service Day, High-Deductible Health Plans Brown Bag Seminar, and Thrift Savings Plan (TSP) Overview Seminar.
Source: http://hr.od.nih.gov/benefits/news/calendar.htm
Ashlee Simpson Ashley Greene Ashley Olsen Ashley Scott Ashley Tappin
Usher Stepson Kile Glover's Funeral Set For Friday
The 11-year-old will be laid to rest in Atlanta after being taken off life support.
By Nadeska Alexis
<P><a href="/news/articles/1689206/ushers-stepson-declared-brain-dead-after-jet-ski-accident.jhtml">Usher's stepson Kile Glover</a> will be laid to rest during a funeral service scheduled to take place in Atlanta on Friday. The 11-year-old died from heart failure last week after being <a href="/news/articles/1690157/usher-stepson-kile-glover-taken-off-life-support.jhtml">taken off life support</a> following a tragic jet-ski accident in early July.</P><P>Glover, who is the son of Usher ex-wife Tameka Foster and Atlanta TV executive Ryan Glover, was struck by a jet ski on Atlanta's Lake Lanier on July 6 while riding an inner tube with a friend. He was immediately airlifted to the hospital, where doctors <a href="/news/articles/1689206/ushers-stepson-declared-brain-dead-after-jet-ski-accident.jhtml">pronounced him brain-dead</a>. Glover was removed from life support last weekend, after his family previously issued statements asking fans for their prayers.</P><P>According to the <a href="http://www.ajc.com/news/atlanta/funeral-for-kile-glover-1484629.html" target="_blank"><i>Atlanta Journal-Constitution,</i></a> the funeral will be held at the Wieuca Road Baptist Church on Peachtree Road in Atlanta at 11 a.m. on Friday.</P><P>"We know God's in control, and are leaning on our faith in Him and His word at this most difficult time," the family said in a statement following the accident. "We firmly believe in the power of prayer and ask that you all continue to pray and lift Kile up, as it's the best way we can all support him now."</P><P>The man driving the jet ski that struck Glover was identified as 38-year-old family friend Jeffrey S. Hubbard. Police have not decided to press any charges so far. A second victim, a 15-year-old girl, was also injured in the accident, but she's said to be recovering after suffering from a broken arm and a cut on the head.</P>
Related ArtistsSource:
http://www.mtv.com/news/articles/1690514/usher-stepson-kile-glover-funeral-date.jhtml
Catherine Bell Chandra West Charisma Carpenter Charli Baltimore Charlies Angels
CDC's 11th International Symposium on Biosafety: January 23-27, Atlanta, GA
The Office of Health and Safety of the Centers for Disease Control and Prevention (CDC) is presenting the "11th International Symposium on Biosafety" on January 23-27, 2010 in Atlanta, Georgia. Program information can be found on the OLAW web site in the Education Section under Workshops and Conferences.
Source: http://grants.nih.gov/grants/olaw/newsarchive_2009.htm#20091201
Gretha Cavazzoni Gwen Stefani Halle Berry Hayden Panettiere Haylie Duff
iAd Producer 3.2: Release notes
iAd Producer makes it easy for you to design and assemble rich interactive iAd content without any programming.
Source: http://support.apple.com/kb/HT4464
AnnaLynne McCord Anne Marie Kortright April Scott Arielle Kebbel Ashanti
Usher - DJ Got Us Fallin' In Love
- Artist: Usher
- Label: LaFace
- Director:
- Album: The Number of Magic
Source:
http://www.mtv.com/overdrive/?artist=1270&vid=555426
Ashanti Ashlee Simpson Ashley Greene Ashley Olsen Ashley Scott
AVMA Guidelines on Euthanasia Comment Period: Part 2
AVMA members are invited to review and comment on the second of three parts of a draft of revisions to the AVMA Guidelines on Euthanasia. Because the draft is lengthy, it is being posted for comment on the AVMA website in three parts over a several week period. Part three of the draft will be posted on July 15. Comments may be submitted through August 1, 2011 at http://www.avma.org/issues/animal_welfare/euthanasia_guidelines/default.asp.
Source: http://grants.nih.gov/grants/olaw/newsarchive_2011.htm#20110712
Gwen Stefani Halle Berry Hayden Panettiere Haylie Duff Heidi Klum
IACUC 101/201 PLUS Workshops: October 7-8, Chicago, IL
IACUC 101 and 201 PLUS Workshops will be held on October 7 and 8, 2009 in Chicago, Illinois. Northwestern University and Loyola University Medical Center will host the programs with support from NIH OLAW, USDA APHIS Animal Care, and AAALAC. Program and registration information can be found on the OLAW website in the Education Section under IACUC 101 Series.
Source: http://grants.nih.gov/grants/olaw/newsarchive_2009.htm#20090910
Jill Wagner Zooey Deschanel Aaliyah Abbie Cornish Adriana Lima
Wednesday, 14 November 2012
A New Transmission Blocking Vaccine for Leishmania Infection
A novel transmission blocking vaccine has been developed that can eliminate or reduce the number of Leishmania chagasi parasites in the gut of the sand fly species, Lutzomyia longipalpis. The vaccine involves the production of antibodies to the sand fly midgut protein, LP1, which is normally expressed in the midgut of the sand fly during a blood meal. This vaccine could potentially block parasite transmission from the sand fly to mammalian hosts and significantly reduce the incidence of leishmaniasis in endemic areas of the world such as Brazil, India, and Indonesia where leishmaniasis accounts for over 58,000 deaths annually.
Studies have shown that LP1 antibodies produced by immunized mice are able to reduce the number of L. chagasi parasites that develop in the midgut of Lu. longipalpis. These results illustrate the potential use of the protein as a vaccine to immunize dogs and protect humans from visceral leishmaniasis transmitted by the sand flies that feed on the infected, vaccinated dogs. In endemic areas such as Brazil where dogs are the principal reservoir for L. chagasi, the LPl antigen alone or in combination with other sand fly midgut proteins could be used to immunize household pets and stray dogs. Vaccinated dogs will produce antibodies to LPl, and once a sand fly feeds on blood from the infected and vaccinated dogs, the antibodies will inhibit development of the parasite in the gut of the sand fly. This approach can effectively block Leishmania transmission to human hosts. Such vaccines have the potential to reduce the risk of humans acquiring leishmaniasis without the risks involved in human vaccination. CRADA Opportunity: The NIAID, OTD is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize "A New Transmission Blocking Vaccine for Leishmania Infection". Please contact Dana Hsu at 301-496-2400 for more information.
Studies have shown that LP1 antibodies produced by immunized mice are able to reduce the number of L. chagasi parasites that develop in the midgut of Lu. longipalpis. These results illustrate the potential use of the protein as a vaccine to immunize dogs and protect humans from visceral leishmaniasis transmitted by the sand flies that feed on the infected, vaccinated dogs. In endemic areas such as Brazil where dogs are the principal reservoir for L. chagasi, the LPl antigen alone or in combination with other sand fly midgut proteins could be used to immunize household pets and stray dogs. Vaccinated dogs will produce antibodies to LPl, and once a sand fly feeds on blood from the infected and vaccinated dogs, the antibodies will inhibit development of the parasite in the gut of the sand fly. This approach can effectively block Leishmania transmission to human hosts. Such vaccines have the potential to reduce the risk of humans acquiring leishmaniasis without the risks involved in human vaccination. CRADA Opportunity: The NIAID, OTD is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize "A New Transmission Blocking Vaccine for Leishmania Infection". Please contact Dana Hsu at 301-496-2400 for more information.
Source: http://www.ott.nih.gov/Technologies/abstractDetails.aspx?RefNo=2086
Giulianna Ramirez Grace Park Gretha Cavazzoni Gwen Stefani Halle Berry
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